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Influenza A virus polymerase co-opts distinct sets of host proteins for RNA traInfluenza A virus polymerase co-opts distinct sets of host proteins for RNA transcription or replication.
Rasmussen AB, Swann OC, Brown JC, Sukhova K, Liu N, Brown MD, Levitt CJL, Martin-Sancho L, Sheppard CM, Barclay WS. Cell Chem Biol. 2026 Mar 19;33(3):338-352.e7. doi: 10.1016/j.chembiol.2026.02.003.
Integrative multi-omics analysis in vivo identifies influenza virus host factors.
Shriver LP, Polacco BJ, Eckhardt M, Chang MW, Martínez-Romero C, Adkins-Travis K, Cahalane C, Haas K, Stein DA, Fourati S, Martin-Sancho L, Metreveli G, Johnson JR, Muñoz-Moreno R, Newton BW, Kaake RM, Zhou Y, Jimenez-Morales D, VonDollen J, Verschueren E, Swaney DL, Nguyen TT, Stevenson EJ, Stancliffe E, Patti GJ, Albrecht R, Moulton HM, Pache L, Sekaly RP, Benner C, Hultquist JF, Chanda SK, Garcia-Sastre A, Krogan NJ. iScience. 2025 Sep 24;28(11):113644. doi: 10.1016/j.isci.2025.113644.
Global siRNA screen identifies human host factors critical for SARS-CoV-2 replication and late stages of infection.
Yin X, Pu Y, Yuan S, Pache L, Churas C, Weston S, Riva L, Simons LM, Cisneros WJ, Clausen T, Biddle G, Doss-Gollin S, Deming M, De Jesus PD, Kim HN, Fuentes D, Whitelock JM, Esko JD, Lord MS, Mena I, García-Sastre A, Hultquist JF, Frieman MB, Ideker T, Pratt D, Martin-Sancho L, Chanda SK. PLoS Biol. 2025 Jun 12;23(6):e3002738. doi: 10.1371/journal.pbio.3002738.
Live imaging of airway epithelium reveals that mucociliary clearance modulates SARS-CoV-2 spread.
Becker ME, Martin-Sancho L, Simons LM, McRaven MD, Chanda SK, Hultquist JF, Hope TJ. Nat Commun. 2024 Nov 2;15(1):9480. doi: 10.1038/s41467-024-53791-4.
Proteomic and genetic analyses of influenza A viruses identify pan-viral host targets.
Haas KM, McGregor MJ, Bouhaddou M, Polacco BJ, Kim EY, Nguyen TT, Newton BW, Urbanowski M, Kim H, Williams MAP, Rezelj VV, Hardy A, Fossati A, Stevenson EJ, Sukerman E, Kim T, Penugonda S, Moreno E, Braberg H, Zhou Y, Metreveli G, Harjai B, Tummino TA, Melnyk JE, Soucheray M, Batra J, Pache L, Martin-Sancho L, Carlson-Stevermer J, Jureka AS, Basler CF, Shokat KM, Shoichet BK, Shriver LP, Johnson JR, Shaw ML, Chanda SK, Roden DM, Carter TC, Kottyan LC, Chisholm RL, Pacheco JA, Smith ME, Schrodi SJ, Albrecht RA, Vignuzzi M, Zuliani-Alvarez L, Swaney DL, Eckhardt M, Wolinsky SM, White KM, Hultquist JF, Kaake RM, García-Sastre A, Krogan NJ. Nat Commun. 2023 Sep 27;14(1):6030. doi: 10.1038/s41467-023-41442-z.
Activation of the Interferon Pathway in Trophoblast Cells Productively Infected with SARS-CoV-2.
Kallol S, Martin-Sancho L, Morey R, Aisagbonhi O, Pizzo D, Meads M, Chanda SK, Soncin F. Stem Cells Dev. 2023 May;32(9-10):225-236. doi: 10.1089/scd.2022.0255.
SARS-CoV-2 infects human brain organoids causing cell death and loss of synapses that can be rescued by treatment with Sofosbuvir.
Mesci P, de Souza JS, Martin-Sancho L, Macia A, Saleh A, Yin X, Snethlage C, Adams JW, Avansini SH, Herai RH, Almenar-Queralt A, Pu Y, Szeto RA, Goldberg G, Bruck PT, Papes F, Chanda SK, Muotri AR. PLoS Biol. 2022 Nov 3;20(11):e3001845. doi: 10.1371/journal.pbio.3001845.
Common and species-specific molecular signatures, networks, and regulators of influenza virus infection in mice, ferrets, and humans.
Forst CV, Martin-Sancho L, Tripathi S, Wang G, Dos Anjos Borges LG, Wang M, Geber A, Lashua L, Ding T, Zhou X, Carter CE, Metreveli G, Rodriguez-Frandsen A, Urbanowski MD, White KM, Stein DA, Moulton H, Chanda SK, Pache L, Shaw ML, Ross TM, Ghedin E, García-Sastre A, Zhang B. Sci Adv. 2022 Oct 7;8(40):eabm5859. doi: 10.1126/sciadv.abm5859.
Sec61 Inhibitor Apratoxin S4 Potently Inhibits SARS-CoV-2 and Exhibits Broad-Spectrum Antiviral Activity.
Pohl MO, Martin-Sancho L, Ratnayake R, White KM, Riva L, Chen QY, Lieber G, Busnadiego I, Yin X, Lin S, Pu Y, Pache L, Rosales R, Déjosez M, Qin Y, De Jesus PD, Beall A, Yoh S, Hale BG, Zwaka TP, Matsunaga N, García-Sastre A, Stertz S, Chanda SK, Luesch H. ACS Infect Dis. 2022 Jul 8;8(7):1265-1279. doi: 10.1021/acsinfecdis.2c00008.
Synthetic lethality-based prediction of anti-SARS-CoV-2 targets.
Pal LR, Cheng K, Nair NU, Martin-Sancho L, Sinha S, Pu Y, Riva L, Yin X, Schischlik F, Lee JS, Chanda SK, Ruppin E. iScience. 2022 May 20;25(5):104311. doi: 10.1016/j.isci.2022.104311.
Development of an In Vivo Probe to Track SARS-CoV-2 Infection in Rhesus Macaques.
Madden PJ, Arif MS, Becker ME, McRaven MD, Carias AM, Lorenzo-Redondo R, Xiao S, Midkiff CC, Blair RV, Potter EL, Martin-Sancho L, Dodson A, Martinelli E, Todd JM, Villinger FJ, Chanda SK, Aye PP, Roy CJ, Roederer M, Lewis MG, Veazey RS, Hope TJ. Front Immunol. 2021 Dec 24;12:810047. doi: 10.3389/fimmu.2021.810047.
Genome-scale metabolic modeling reveals SARS-CoV-2-induced metabolic changes and antiviral targets.
Cheng K, Martin-Sancho L, Pal LR, Pu Y, Riva L, Yin X, Sinha S, Nair NU, Chanda SK, Ruppin E. Mol Syst Biol. 2021 Nov;17(11):e10260. doi: 10.15252/msb.202110260.
Restriction factor compendium for influenza A virus reveals a mechanism for evasion of autophagy.
Martin-Sancho L, Tripathi S, Rodriguez-Frandsen A, Pache L, Sanchez-Aparicio M, McGregor MJ, Haas KM, Swaney DL, Nguyen TT, Mamede JI, Churas C, Pratt D, Rosenthal SB, Riva L, Nguyen C, Beltran-Raygoza N, Soonthornvacharin S, Wang G, Jimenez-Morales D, De Jesus PD, Moulton HM, Stein DA, Chang MW, Benner C, Ideker T, Albrecht RA, Hultquist JF, Krogan NJ, García-Sastre A, Chanda SK. Nat Microbiol. 2021 Oct;6(10):1319-1333. doi: 10.1038/s41564-021-00964-2.
The Compound SBI-0090799 Inhibits Zika Virus Infection by Blocking De NovoFormation of the Membranous Replication Compartment.
Riva L, Goellner S, Biering SB, Huang CT, Rubanov AN, Haselmann U, Warnes CM, De Jesus PD, Martin-Sancho L, Terskikh AV, Harris E, Pinkerton AB, Bartenschlager R, Chanda SK. J Virol. 2021 Oct 27;95(22):e0099621. doi: 10.1128/JVI.00996-21.
Rising to the challenge of COVID-19: Working on SARS-CoV-2 during the pandemic.
Stern-Ginossar N, Kanneganti TD, Cameron CE, Lou Z, Cherry S, Abraham J, Martin-Sancho L. Mol Cell. 2021 Jun 3;81(11):2261-2265. doi: 10.1016/j.molcel.2021.05.021.
Functional landscape of SARS-CoV-2 cellular restriction.
Martin-Sancho L, Lewinski MK, Pache L, Stoneham CA, Yin X, Becker ME, Pratt D, Churas C, Rosenthal SB, Liu S, Weston S, De Jesus PD, O'Neill AM, Gounder AP, Nguyen C, Pu Y, Curry HM, Oom AL, Miorin L, Rodriguez-Frandsen A, Zheng F, Wu C, Xiong Y, Urbanowski M, Shaw ML, Chang MW, Benner C, Hope TJ, Frieman MB, García-Sastre A, Ideker T, Hultquist JF, Guatelli J, Chanda SK. Mol Cell. 2021 Jun 17;81(12):2656-2668.e8. doi: 10.1016/j.molcel.2021.04.008.
MDA5 Governs the Innate Immune Response to SARS-CoV-2 in Lung Epithelial Cells.
Yin X, Riva L, Pu Y, Martin-Sancho L, Kanamune J, Yamamoto Y, Sakai K, Gotoh S, Miorin L, De Jesus PD, Yang CC, Herbert KM, Yoh S, Hultquist JF, García-Sastre A, Chanda SK. Cell Rep. 2021 Jan 12;34(2):108628. doi: 10.1016/j.celrep.2020.108628.
SARS-CoV-2 Orf6 hijacks Nup98 to block STAT nuclear import and antagonize interferon signaling.
Miorin L, Kehrer T, Sanchez-Aparicio MT, Zhang K, Cohen P, Patel RS, Cupic A, Makio T, Mei M, Moreno E, Danziger O, White KM, Rathnasinghe R, Uccellini M, Gao S, Aydillo T, Mena I, Yin X, Martin-Sancho L, Krogan NJ, Chanda SK, Schotsaert M, Wozniak RW, Ren Y, Rosenberg BR, Fontoura BMA, García-Sastre A. Proc Natl Acad Sci U S A. 2020 Nov 10;117(45):28344-28354. doi: 10.1073/pnas.2016650117.
Discovery of SARS-CoV-2 antiviral drugs through large-scale compound repurposing.
Riva L, Yuan S, Yin X, Martin-Sancho L, Matsunaga N, Pache L, Burgstaller-Muehlbacher S, De Jesus PD, Teriete P, Hull MV, Chang MW, Chan JF, Cao J, Poon VK, Herbert KM, Cheng K, Nguyen TH, Rubanov A, Pu Y, Nguyen C, Choi A, Rathnasinghe R, Schotsaert M, Miorin L, Dejosez M, Zwaka TP, Sit KY, Martinez-Sobrido L, Liu WC, White KM, Chapman ME, Lendy EK, Glynne RJ, Albrecht R, Ruppin E, Mesecar AD, Johnson JR, Benner C, Sun R, Schultz PG, Su AI, García-Sastre A, Chatterjee AK, Yuen KY, Chanda SK. Nature. 2020 Oct;586(7827):113-119. doi: 10.1038/s41586-020-2577-1.
mRNA display with library of even-distribution reveals cellular interactors of influenza virus NS1.
Du Y, Hultquist JF, Zhou Q, Olson A, Tseng Y, Zhang TH, Hong M, Tang K, Chen L, Meng X, McGregor MJ, Dai L, Gong D, Martin-Sancho L, Chanda S, Li X, Bensenger S, Krogan NJ, Sun R. Nat Commun. 2020 May 15;11(1):2449. doi: 10.1038/s41467-020-16140-9.
Viral Determinants in H5N1 Influenza A Virus Enable Productive Infection of HeLa Cells.
Rodriguez-Frandsen A, Martin-Sancho L, Gounder AP, Chang MW, Liu WC, De Jesus PD, von Recum-Knepper J, Dutra MS, Huffmaster NJ, Chavarria M, Mena I, Riva L, Nguyen CB, Dobariya S, Herbert KM, Benner C, Albrecht RA, García-Sastre A, Chanda SK. J Virol. 2020 Jan 31;94(4):e01410-19. doi: 10.1128/JVI.01410-19.
RNAi-based small molecule repositioning reveals clinically approved urea-based kinase inhibitors as broadly active antivirals.
Lesch M, Luckner M, Meyer M, Weege F, Gravenstein I, Raftery M, Sieben C, Martin-Sancho L, Imai-Matsushima A, Welke RW, Frise R, Barclay W, Schönrich G, Herrmann A, Meyer TF, Karlas A. PLoS Pathog. 2019 Mar 18;15(3):e1007601. doi: 10.1371/journal.ppat.1007601.
Long-Term Culture of Distal Airway Epithelial Cells Allows Differentiation Towards Alveolar Epithelial Cells Suited for Influenza Virus Studies.
Imai-Matsushima A, Martin-Sancho L, Karlas A, Imai S, Zoranovic T, Hocke AC, Mollenkopf HJ, Berger H, Meyer TF. EBioMedicine. 2018 Jul;33:230-241. doi: 10.1016/j.ebiom.2018.05.032.